Heparanase-2 protein and peptides have a protective effect on experimental glomerulonephritis and diabetic nephropathy

Introduction: The endothelial glycocalyx degrading enzyme heparanase-1 (HPSE1) is a major contributor to kidney diseases, such as glomerulonephritis and diabetic nephropathy. Therefore, inhibition of HPSE1 could be an interesting therapeutic strategy to treat glomerular diseases. A possible HPSE1 in...

Full description

Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Baranca Buijsers, Marjolein Garsen, Mark de Graaf, Marinka Bakker-van Bebber, Chunming Guo, Xue Li, Johan van der Vlag
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-04-01
Subjects:	heparanase-1 heparanase-2 endothelial glycocalyx degradation proteinuria glomerulonephritis diabetic nephropathy
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1098184/full