Assessing the gene silencing potential of AuNP-based approaches on conventional 2D cell culture versus 3D tumor spheroid

Three-dimensional (3D) cell culture using tumor spheroids provides a crucial platform for replicating tissue microenvironments. However, effective gene modulation via nanoparticle-based transfection remains a challenge, often facing delivery hurdles. Gold nanoparticles (AuNPs) with their tailored sy...

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Bibliographic Details

Published in:	Frontiers in Bioengineering and Biotechnology
Main Authors:	Beatriz B. Oliveira, Alexandra R. Fernandes, Pedro Viana Baptista
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-02-01
Subjects:	gold nanoparticles gene silencing 3D spheroids cancer models c-MYC
Online Access:	https://www.frontiersin.org/articles/10.3389/fbioe.2024.1320729/full