Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2

Summary: Niacin, an age-old lipid-lowering drug, acts through the hydroxycarboxylic acid receptor 2 (HCAR2), a G-protein-coupled receptor (GPCR). Yet, its use is hindered by side effects like skin flushing. To address this, specific HCAR2 agonists, like MK-6892 and GSK256073, with fewer adverse effe...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Shengnan Zhu, Qingning Yuan, Xinzhu Li, Xinheng He, Shiyi Shen, Dongxue Wang, Junrui Li, Xi Cheng, Xiaoqun Duan, H. Eric Xu, Jia Duan
Format:	Article
Language:	English
Published:	Elsevier 2023-11-01
Subjects:	CP: Molecular biology CP: Metabolism
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124723014183