Antibody-based binding domain fused to TCRγ chain facilitates T cell cytotoxicity for potent anti-tumor response

Abstract Chimeric antigen receptor T-cell (CAR-T) therapy has demonstrated potent clinical efficacy in the treatment of hematopoietic malignancies. However, the application of CAR-T in solid tumors has been limited due in part to the expression of inhibitory molecules in the tumor microenvironment,...

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發表在:	Oncogenesis
Main Authors:	Zhao Chen, Changyou Lin, Hong Pei, Xiaomei Yuan, Jia Xu, Mingwei Zou, Xinyuan Zhang, Amber Fossier, Meizhu Liu, Seungah Goo, Lei Lei, Jia Yang, Catherine Novick, Jiqing Xu, Ge Ying, Zhihong Zhou, Jianbo Wu, Chunyi Tang, Wenying Zhang, Zhenping Wang, Zhihao Wang, Huitang Zhang, Wenzhong Guo, Qidong Hu, Henry Ji, Runqiang Chen
格式:	Article
語言:	英语
出版:	Nature Publishing Group 2023-06-01
在線閱讀:	https://doi.org/10.1038/s41389-023-00480-4