Chronic pharmacologic manipulation of dopamine transmission ameliorates metabolic disturbance in Trappc9-linked brain developmental syndrome
Loss-of-function mutations of the gene encoding the trafficking protein particle complex subunit 9 (Trappc9) cause autosomal recessive intellectual disability and obesity by unknown mechanisms. Genome-wide analysis links Trappc9 to nonalcoholic fatty liver disease (NAFLD). Trappc9-deficient mice hav...
| الحاوية / القاعدة: | JCI Insight |
|---|---|
| المؤلفون الرئيسيون: | , , , , , , , |
| التنسيق: | مقال |
| اللغة: | الإنجليزية |
| منشور في: |
American Society for Clinical investigation
2024-08-01
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://doi.org/10.1172/jci.insight.181339 |