Defining Structure‐Function Relationships of Amphiphilic Excipients Enables Rational Design of Ultra‐Stable Biopharmaceuticals

Abstract Biopharmaceuticals are the fastest‐growing class of drugs in the healthcare industry, but their global reach is severely limited by their propensity for rapid aggregation. Currently, surfactant excipients such as polysorbates and poloxamers are used to prevent protein aggregation, which sig...

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Bibliographic Details

Published in:	Advanced Science
Main Authors:	Alexander N. Prossnitz, Leslee T. Nguyen, Noah Eckman, Suraj Borkar, Samantha Tetef, Anton A. A. Autzen, Gerald G. Fuller, Eric A. Appel
Format:	Article
Language:	English
Published:	Wiley 2025-02-01
Subjects:	bioengineering biomaterials biopharmaceuticals excipients polymer science
Online Access:	https://doi.org/10.1002/advs.202409604