Cystathionine γ-lyase inhibits mitochondrial oxidative stress by releasing H2S nearby through the AKT/NRF2 signaling pathway

Cystathionine γ-lyase (CSE) is a major enzyme that produces hydrogen sulfide (H2S). Herein, we report how CSE plays a previously unknown role in regulating the antioxidant effects of the mitochondria in human umbilical vein endothelial cells by releasing H2S nearby under stress conditions. We found...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Tingting Xiao, Shun Chen, Ge Yan, Junmin Zheng, Qingzhu Qiu, Shujia Lin, Yanfang Zong, Haishuang Chang, Alex Chia Yu Chang, Ying Wu, Cuilan Hou
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-07-01
Subjects:	hydrogen sulfide accelerated aging mitochondria PI3K-AKT pathway cystathionine γ-lyase
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1374720/full