Attenuating ABHD17 Isoforms Augments the S-acylation and Function of NOD2 and a Subset of Crohn’s Disease-associated NOD2 VariantsSummary

Background & Aims: NOD2 is an intracellular innate immune receptor that detects bacterial peptidoglycan fragments. Although nominally soluble, some NOD2 is associated with the plasma membrane and endosomal compartments for microbial surveillance. This membrane targeting is achieved through p...

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Bibliographic Details

Published in:	Cellular and Molecular Gastroenterology and Hepatology
Main Authors:	Charneal L. Dixon, Noah R. Martin, Micah J. Niphakis, Benjamin F. Cravatt, Gregory D. Fairn
Format:	Article
Language:	English
Published:	Elsevier 2025-01-01
Subjects:	ABHD17 Acyl Protein Thioesterase Crohn’s Disease IL-8 Inflammation NOD2
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352345X25000323