Polydeoxyribonucleotide ameliorates IL-1β-induced impairment of chondrogenic differentiation in human bone marrow-derived mesenchymal stem cells

Abstract Osteoarthritis (OA) is a degenerative disease of the joints, prevalent worldwide. Polydeoxyribonucleotide (PDRN) is used for treating knee OA. However, the role of PDRN in IL-1β-induced inflammatory responses in human bone marrow-derived mesenchymal stem cells (hBMSCs) remains unknown. Here...

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Bibliographic Details
Published in:Scientific Reports
Main Authors: Ahreum Baek, Dawoon Baek, Sung Hoon Kim, Jinyoung Kim, Geneva Rose Notario, Do‑Won Lee, Hyun Jung Kim, Sung-Rae Cho
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Subjects:
Polydeoxyribonucleotide
Mesenchymal stem cell
Chondrogenic differentiation
Interleukin-1β
Osteoarthritis
Online Access:https://doi.org/10.1038/s41598-024-77264-2

Internet

https://doi.org/10.1038/s41598-024-77264-2

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