Ancient Evolutionary Origin of Intrinsically Disordered Cancer Risk Regions

Cancer is a heterogeneous genetic disease that alters the proper functioning of proteins involved in key regulatory processes such as cell cycle, DNA repair, survival, or apoptosis. Mutations often accumulate in hot-spots regions, highlighting critical functional modules within these proteins that n...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Mátyás Pajkos, András Zeke, Zsuzsanna Dosztányi
Format:	Article
Language:	English
Published:	MDPI AG 2020-07-01
Subjects:	intrinsically disordered regions linear motifs gene duplications de novo evolutionary origin
Online Access:	https://www.mdpi.com/2218-273X/10/8/1115