C3aR Antagonist Alleviates C3a Induced Tubular Profibrotic Phenotype Transition via Restoring PPARα/CPT-1α Mediated Mitochondrial Fatty Acid Oxidation in Renin-Dependent Hypertension

Background: Renin-dependent hypertension with tubulointerstitial injury remains a problem with high prevalence in the clinic. However, whether and how renin participates in tubulointerstitial injury remains incompletely understood. New evidence suggests that renin cleaves C3 into C3a and C3b. In the...

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Bibliographic Details

Published in:	Frontiers in Bioscience-Landmark
Main Authors:	Chongjian Wang, Zhiyu Wang, Jing Xu, Hongkun Ma, Kexin Jin, Tingting Xu, Xiaoxia Pan, Xiaobei Feng, Wen Zhang
Format:	Article
Language:	English
Published:	IMR Press 2023-10-01
Subjects:	hypertension-induced kidney injury renin c3a c3a receptor mitochondrial fatty acid oxidation profibrotic phenotype transition
Online Access:	https://www.imrpress.com/journal/FBL/28/10/10.31083/j.fbl2810238