Intramuscular Expression of Plasmid-Encoded FVII-Fc Immunoconjugate for Tumor Immunotherapy by Targeting Tumoral Blood Vessels and Cells

Tissue factor (TF) has been confirmed to be specifically expressed by vascular endothelial cells (VECs) in solid tumors and certain types of malignant tumor cells. Coagulation factor VII (FVII) can specifically bind to TF with high affinity, so the FVII-TF interaction provides an ideal target for tu...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Liping Ma, Guanru Wang, Sijia Liu, Feng Bi, Ming Liu, Gang Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-05-01
Subjects:	FVII-Fc immunoconjugate intramuscular gene expression L/E technique tumor immunotherapy gene therapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2021.638591/full