Recognition of yeast β-glucan particles triggers immunometabolic signaling required for trained immunity

Summary: Fungal β-glucans are major drivers of trained immunity which increases long-term protection against secondary infections. Heterogeneity in β-glucan source, structure, and solubility alters interaction with the phagocytic receptor Dectin-1 and could impact strategies to improve trained immun...

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Bibliographic Details

Published in:	iScience
Main Authors:	Cian J.H. Horneck Johnston, Anna E. Ledwith, Mimmi L.E. Lundahl, Hugo Charles-Messance, Emer E. Hackett, Simon D. O’Shaughnessy, Jonah Clegg, Hannah Prendeville, John P. McGrath, Aaron M. Walsh, Sarah Case, Hollie Austen Byrne, Parth Gautam, Elaine Dempsey, Sinead C. Corr, Frederick J. Sheedy
Format:	Article
Language:	English
Published:	Elsevier 2024-03-01
Subjects:	Physiology Molecular biology Immunology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004224002517