Thalidomide Attenuates Mast Cell Activation by Upregulating SHP-1 Signaling and Interfering with the Action of CRBN

Allergy is a chronic inflammatory disease, and its incidence has increased worldwide in recent years. Thalidomide, which was initially used as an anti-emetic drug but was withdrawn due to its teratogenic effects, is now used to treat blood cancers. Although the anti-inflammatory and immunomodulatory...

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Bibliographic Details

Published in:	Cells
Main Authors:	Hyeun-Wook Chang, Kyeong-Hwa Sim, Youn-Ju Lee
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Subjects:	thalidomide mast cell allergy Src homology 2 domain-containing phosphatase-1 adenosine monophosphate-activated protein kinase cereblon
Online Access:	https://www.mdpi.com/2073-4409/12/3/469