Plasticity of Type I Interferon-Mediated Responses in Cancer Therapy: From Anti-tumor Immunity to Resistance

The efficacy of several therapeutic strategies against cancer, including cytotoxic drugs, radiotherapy, targeted immunotherapies and oncolytic viruses, depend on intact type I interferon (IFN) signaling for the promotion of both direct (tumor cell inhibition) and indirect (anti-tumor immune response...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Megha Budhwani, Roberta Mazzieri, Riccardo Dolcetti
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-08-01
Subjects:	interferons cancer immunotherapy immune responses resistance mechanisms tumor microenvironment
Online Access:	https://www.frontiersin.org/article/10.3389/fonc.2018.00322/full