2′-Fucosyllactose mitigates cognitive deficits in Alzheimer models: targeting amyloid pathology, oxidative stress, and synaptic plasticity

IntroductionThe development of new drugs for Alzheimer’s disease (AD) remains a major challenge due to the disorder’s complex and multifactorial nature. 2′-Fucosyllactose (2′-FL), a human milk oligosaccharide, has demonstrated promising neuroprotective properties. However, its effects on AD-related...

Full description

Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Yeasmin Akter Munni, Khoa Nguyen Tran, Seon-Min Jeon, Meeyul Hwang, Jong-Won Yoon, Young-Ha Song, Tae Woo Oh, Sang Il Gum, In-Jun Yang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Subjects:	2′-fucosyllactose Alzheimer’s disease cognitive function oxidative stress synaptic plasticity 5xFAD
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1598030/full