Short-term overnutrition induces white adipose tissue insulin resistance through sn-1,2-diacylglycerol/PKCε/insulin receptor Thr1160 phosphorylation

White adipose tissue (WAT) insulin action has critical anabolic function and is dysregulated in overnutrition. However, the mechanism of short-term high-fat diet–induced (HFD-induced) WAT insulin resistance (IR) is poorly understood. Based on recent evidences, we hypothesize that a short-term HFD ca...

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發表在:	JCI Insight
Main Authors:	Kun Lyu, Dongyan Zhang, Joongyu Song, Xiruo Li, Rachel J. Perry, Varman T. Samuel, Gerald I. Shulman
格式:	Article
語言:	英语
出版:	American Society for Clinical investigation 2021-02-01
主題:	Endocrinology Metabolism
在線閱讀:	https://doi.org/10.1172/jci.insight.139946