Biophysical characterization of PVR family interactions and therapeutic antibody recognition to TIGIT

The clinical successes of immune checkpoint blockade have invigorated efforts to activate T cell-mediated responses against cancer. Targeting members of the PVR family, consisting of inhibitory receptors TIGIT, CD96, and CD112R, has been an active area of clinical investigation. In this study, the b...

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Bibliographic Details

Published in:	mAbs
Main Authors:	SJ J. Diong, Aarti Jashnani, Andrew W. Drake, Christine Bee, Felix Findeisen, Gavin Dollinger, Feng Wang, Arvind Rajpal, Pavel Strop, Peter S. Lee
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2023-12-01
Subjects:	Antibody biophysics immunology oncology receptor–ligand interactions
Online Access:	https://www.tandfonline.com/doi/10.1080/19420862.2023.2253788