Synthesis and Preliminary Immunological Evaluation of a Pseudotetrasaccharide Related to a Repeating Unit of the Streptococcus pneumoniae Serotype 6A Capsular Polysaccharide

2-Aminoethyl glycoside of the pseudotetrasaccharide α-d-Glcp-(1→3)-α-l-Rhap-(1→3)-d-Rib-ol-(5-P-2)-α-d-Galp corresponding to a repeating unit of the Streptococcus pneumoniae type 6A capsular polysaccharide has been synthesized. A suitably protected pseudotrisaccharide α-d-Glcp-(1→3)-α-l-Rhap-(1→3)-d...

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Bibliographic Details

Published in:	Frontiers in Molecular Biosciences
Main Authors:	Elena V. Sukhova, Dmitry V. Yashunsky, Ekaterina A. Kurbatova, Elina A. Akhmatova, Yury E. Tsvetkov, Nikolay E. Nifantiev
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-12-01
Subjects:	Streptococcus pneumoniae serotype 6A capsular polysaccharide conjugate vaccines repeating unit phosphodiester synthesis
Online Access:	https://www.frontiersin.org/articles/10.3389/fmolb.2021.754753/full