Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs.

Although ACE2 is the primary receptor for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, a systematic assessment of host factors that regulate binding to SARS-CoV-2 spike protein has not been described. Here, we use whole-genome CRISPR activation to identify host factors con...

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Bibliographic Details

Published in:	PLoS Biology
Main Authors:	Lipin Loo, Matthew A Waller, Cesar L Moreno, Alexander J Cole, Alberto Ospina Stella, Oltin-Tiberiu Pop, Ann-Kristin Jochum, Omar Hasan Ali, Christopher E Denes, Zina Hamoudi, Felicity Chung, Anupriya Aggarwal, Jason K K Low, Karishma Patel, Rezwan Siddiquee, Taeyoung Kang, Suresh Mathivanan, Joel P Mackay, Wolfram Jochum, Lukas Flatz, Daniel Hesselson, Stuart Turville, G Gregory Neely
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2023-02-01
Online Access:	https://doi.org/10.1371/journal.pbio.3001967