Development of the TSR-based computational method to investigate spike and monoclonal antibody interactions

IntroductionMonoclonal antibody (mAb) drug treatments have proven effective in reducing COVID-19-related hospitalizations or fatalities, particularly among high-risk patients. Numerous experimental studies have explored the structures of spike proteins and their complexes with ACE2 or mAbs. These 3D...

Full description

Bibliographic Details

Published in:	Frontiers in Chemistry
Main Authors:	Tarikul I. Milon, Titli Sarkar, Yixin Chen, Jordan M. Grider, Feng Chen, Jun-Yuan Ji, Seetharama D. Jois, Konstantin G. Kousoulas, Vijay Raghavan, Wu Xu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Subjects:	TSR-based method molecular interaction monoclonal antibody spike amino acid structure machine learning
Online Access:	https://www.frontiersin.org/articles/10.3389/fchem.2025.1395374/full