Associations of combined accelerated biological aging and genetic susceptibility with incident dementia: a prospective study in the UK Biobank

Abstract Background Accelerated biological aging has been verified to be a critical risk factor for a number of age-related diseases, but its role in dementia remained unclear. Whether it modified the effects of genetic factors was also unknown. This study evaluated the associations between accelera...

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發表在:	BMC Medicine
Main Authors:	Zirong Ye, Haoxiang Lang, Zishan Xie, Siyu Duan, Bihao Peng, Xiaochun Chen, Ya Fang, Jiawei Xin
格式:	Article
語言:	英语
出版:	BMC 2024-09-01
主題:	UK Biobank Accelerated biological aging Dementia Apolipoprotein E Polygenetic risk score Relative excess risk
在線閱讀:	https://doi.org/10.1186/s12916-024-03640-4