Chronic immune activation and gut barrier dysfunction is associated with neuroinflammation in ART-suppressed SIV+ rhesus macaques.

HIV-associated neurocognitive disorders (HAND) affect ~40% of virally suppressed people with HIV (PWH), however, the precise viral dependent and independent changes to the brain are unclear. Here we characterized the CNS reservoir and immune environment of SIV-infected (SIV+) rhesus macaques during...

Full description

Bibliographic Details

Published in:	PLoS Pathogens
Main Authors:	Sarah J Byrnes, Kathleen Busman-Sahay, Thomas A Angelovich, Skyler Younger, Sol Taylor-Brill, Michael Nekorchuk, Stephen Bondoc, Rachel Dannay, Margaret Terry, Catherine R Cochrane, Trisha A Jenkins, Michael Roche, Claire Deleage, Steven E Bosinger, Mirko Paiardini, Bruce J Brew, Jacob D Estes, Melissa J Churchill
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2023-03-01
Online Access:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011290&type=printable