FLI1 is associated with regulation of DNA methylation and megakaryocytic differentiation in FPDMM caused by a RUNX1 transactivation domain mutation

Abstract Familial platelet disorder with associated myeloid malignancies (FPDMM) is an autosomal dominant disease caused by heterozygous germline mutations in RUNX1. It is characterized by thrombocytopenia, platelet dysfunction, and a predisposition to hematological malignancies. Although FPDMM is a...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Yuki Tanaka, Yuri Nakanishi, Erina Furuhata, Ken-ichi Nakada, Rino Maruyama, Harukazu Suzuki, Takahiro Suzuki
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-06-01
Subjects:	DNA methylation analysis Familial platelet disorder with associated myeloid malignancies FLI1 DNA demethylation Megakaryocytic differentiation
Online Access:	https://doi.org/10.1038/s41598-024-64829-4