ADP-Mediated Upregulation of Expression of CD62P on Human Platelets Is Critically Dependent on Co-Activation of P2Y1 and P2Y12 Receptors

This study probed the differential utilization of P2Y1 and P2Y12 receptors in mobilizing CD62P (P-selectin) from intracellular granules following activation of human platelets with adenosine 5′-diphosphate (ADP, 100 µmol·L⁻¹) Platelet-rich plasma (PRP) was prepared from the bl...

Full description

Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Ronald Anderson, Annette J. Theron, Helen C. Steel, Jan G. Nel, Gregory R. Tintinger
Format:	Article
Language:	English
Published:	MDPI AG 2020-11-01
Subjects:	adenosine 5′-diphosphate cytosolic calcium phospholipase C phosphatidylinositol 3-kinase platelets P2Y1/P2Y12 receptors
Online Access:	https://www.mdpi.com/1424-8247/13/12/420