Analysis of Structures of SARS-CoV-2 Papain-like Protease Bound with Ligands Unveils Structural Features for Inhibiting the Enzyme

The COVID-19 pandemic, driven by the novel coronavirus SARS-CoV-2, has drastically reshaped global health and socioeconomic landscapes. The papain-like protease (PLpro) plays a critical role in viral polyprotein cleavage and immune evasion, making it a prime target for therapeutic intervention. Nume...

Full description

Bibliographic Details

Published in:	Molecules
Main Authors:	Ann Varghese, Jie Liu, Bailang Liu, Wenjing Guo, Fan Dong, Tucker A. Patterson, Huixiao Hong
Format:	Article
Language:	English
Published:	MDPI AG 2025-01-01
Subjects:	SARS CoV-2 papain-like protease PLpro ligands binding sites 3D structures
Online Access:	https://www.mdpi.com/1420-3049/30/3/491