miR-124-3p delivered by exosomes from heme oxygenase-1 modified bone marrow mesenchymal stem cells inhibits ferroptosis to attenuate ischemia–reperfusion injury in steatotic grafts

Abstract Background Steatotic livers tolerate ischemia–reperfusion injury (IRI) poorly, increasing the risk of organ dysfunction. Ferroptosis is considered the initiating factor of organ IRI. Heme oxygenase oxygen-1 (HO-1)-modified bone marrow mesenchymal stem cells (BMMSCs) (HO-1/BMMSCs) can reduce...

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Bibliographic Details

Published in:	Journal of Nanobiotechnology
Main Authors:	Longlong Wu, Xuan Tian, Huaiwen Zuo, Weiping Zheng, Xiang Li, Mengshu Yuan, Xiaorong Tian, Hongli Song
Format:	Article
Language:	English
Published:	BMC 2022-04-01
Subjects:	Ferroptosis Exosomes Bone marrow mesenchymal stem cells miR-124-3p STEAP3 Heme oxygenase oxygen-1
Online Access:	https://doi.org/10.1186/s12951-022-01407-8