LRRK2 kinase inhibition protects against Parkinson's disease-associated environmental toxicants

Idiopathic Parkinson's disease (PD) is epidemiologically linked with exposure to toxicants such as pesticides and solvents, which comprise a wide array of chemicals that pollute our environment. While most are structurally distinct, a common cellular target for their toxicity is mitochondrial d...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Neda M. Ilieva, Eric K. Hoffman, Mohammed A. Ghalib, J. Timothy Greenamyre, Briana R. De Miranda
Format:	Article
Language:	English
Published:	Elsevier 2024-06-01
Subjects:	Parkinson's disease (PD) Gene x environment (GxE) Environmental toxicants Leucine rich repeat kinase 2 (LRRK2) Mitochondria
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996124001219