Molecular Profiling Defines Three Subtypes of Synovial Sarcoma

Abstract Synovial Sarcomas (SS) are characterized by the presence of the SS18::SSX fusion gene, which protein product induce chromatin changes through remodeling of the BAF complex. To elucidate the genomic events that drive phenotypic diversity in SS, we performed RNA and targeted DNA sequencing on...

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الحاوية / القاعدة:	Advanced Science
المؤلفون الرئيسيون:	Yi Chen, Yanhong Su, Xiaofang Cao, Ioannis Siavelis, Isabelle Rose Leo, Jianming Zeng, Panagiotis Tsagkozis, Asle C. Hesla, Andri Papakonstantinou, Xiao Liu, Wen‐Kuan Huang, Binbin Zhao, Cecilia Haglund, Monika Ehnman, Henrik Johansson, Yingbo Lin, Janne Lehtiö, Yifan Zhang, Olle Larsson, Xuexin Li, Felix Haglund de Flon
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Wiley 2024-11-01
الموضوعات:	BAF complex copy number alterations multi‐omics synovial sarcoma transcriptomics
الوصول للمادة أونلاين:	https://doi.org/10.1002/advs.202404510