Enamine Barbiturates and Thiobarbiturates as a New Class of Bacterial Urease Inhibitors

Urease is a therapeutic target associated with several important diseases and health problems. Based on our previous work on the inhibition of glucosidase and other enzymes and exploiting the privileged structure assigned to the (thio)barbiturate (pyrimidine) scaffold, here we tested the capacity of...

Full description

Bibliographic Details

Published in:	Applied Sciences
Main Authors:	M. Ali, Assem Barakat, Ayman El-Faham, Abdullah Mohammed Al-Majid, Sammer Yousuf, Sajda Ashraf, Zaheer Ul-Haq, M. Iqbal Choudhary, Beatriz G. de la Torre, Fernando Albericio
Format:	Article
Language:	English
Published:	MDPI AG 2020-05-01
Subjects:	pyrimidine-trione barbituric thiobarbituric urease inhibitors DFT
Online Access:	https://www.mdpi.com/2076-3417/10/10/3523