Extended dosing (12 cycles) vs conventional dosing (6 cycles) of adjuvant temozolomide in adults with newly diagnosed high-grade gliomas: a randomized, single-blind, two-arm, parallel-group controlled trial

PurposeMaximum safe surgical resection followed by adjuvant chemoradiation and temozolomide chemotherapy is the current standard of care in the management of newly diagnosed high grade glioma. However, there are controversies about the optimal number of adjuvant temozolomide cycles. This study aimed...

Full description

Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Kazem Anvari, Mehdi Seilanian Toussi, Mohammadreza Saghafi, Seyed Alireza Javadinia, Hamidreza Saghafi, James S. Welsh
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-05-01
Subjects:	high grade gliomas adjuvant temozolomide survival extended chemotherapy randomized controlled trial glioblastoma multiforme
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1357789/full