The Spindle Assembly Checkpoint Is Required for Hematopoietic Progenitor Cell Engraftment

Summary: The spindle assembly checkpoint plays a pivotal role in preventing aneuploidy and transformation. Many studies demonstrate impairment of this checkpoint in cancer cells. While leukemia is frequently driven by transformed hematopoietic stem and progenitor cells (HSPCs), the biology of the sp...

Full description

Bibliographic Details

Published in:	Stem Cell Reports
Main Authors:	Andreas Brown, Johannes Pospiech, Karina Eiwen, Darren J. Baker, Bettina Moehrle, Vadim Sakk, Kalpana Nattamai, Mona Vogel, Ani Grigoryan, Hartmut Geiger
Format:	Article
Language:	English
Published:	Elsevier 2017-11-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213671117304241