Sodium formate-induced mitochondrial impairment and cytotoxicity in neuronal cells reveal crucial pathogenic mechanisms underlying diabetic neuropathy and retinopathy
Abstract Formic acid, a toxic one-carbon metabolite formed from methanol and formaldehyde in the body, can cause neuronal dysfunctions. It was recently hypothesized that metabolic formation of toxic one-carbon metabolites (particularly formic acid) under hyperglycemic conditions may contribute to th...
| Published in: | Scientific Reports |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-11312-3 |