Molecular dissection of an immunodominant epitope in Kv1.2-exclusive autoimmunity

IntroductionSubgroups of autoantibodies directed against voltage-gated potassium channel (Kv) complex components have been associated with immunotherapy-responsive clinical syndromes. The high prevalence and the role of autoantibodies directly binding Kv remain, however, controversial. Our objective...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Ivan Talucci, Friederike A. Arlt, Kai O. Kreissner, Mahoor Nasouti, Anna-Lena Wiessler, Ramona Miske, Swantje Mindorf, Inga Dettmann, Mehrnaz Moniri, Markus Bayer, Peter Broegger Christensen, Ilya Ayzenberg, Andrea Kraft, Matthias Endres, Lars Komorowski, Carmen Villmann, Kathrin Doppler, Harald Prüss, Hans M. Maric
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-04-01
Subjects:	autoantibodies Kv channel KCNA2 autoimmune encephalitis epitope mapping immunodominant antigen
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1329013/full