Repurposing Antimalarial Pyronaridine as a DNA Repair Inhibitor to Exploit the Full Potential of Gold-Nanoparticle-Mediated Radiation Response

Radiation therapy (RT) is frequently used to locally treat tumors. One of the major issues in RT is normal tissue toxicity; thus, it is necessary to limit dose escalation for enhanced local control in patients that have locally advanced tumors. Integrating radiosensitizing agents such as gold nanopa...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Nolan Jackson, Abdulaziz Alhussan, Kyle Bromma, David Jay, James C. Donnelly, Frederick G. West, Afsaneh Lavasanifar, Michael Weinfeld, Wayne Beckham, Devika B. Chithrani
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Subjects:	gold nanoparticles pyronaridine cancer cells radiotherapy DNA repair ERCC1-XPF
Online Access:	https://www.mdpi.com/1999-4923/14/12/2795