Multiprotein GLI Transcriptional Complexes as Therapeutic Targets in Cancer

The Hedgehog signaling pathway functions in both embryonic development and adult tissue homeostasis. Importantly, its aberrant activation is also implicated in the progression of multiple types of cancer, including basal cell carcinoma and medulloblastoma. GLI transcription factors function as the u...

Full description

Bibliographic Details

Published in:	Life
Main Authors:	Fan Yang, Daniel T. Wynn, Chen Shen, Nagi G. Ayad, David J. Robbins
Format:	Article
Language:	English
Published:	MDPI AG 2022-11-01
Subjects:	GLI transcriptional complex hedgehog signaling epigenetic regulation
Online Access:	https://www.mdpi.com/2075-1729/12/12/1967