ZAR1 and ZAR2 orchestrate the dynamics of maternal mRNA polyadenylation during mouse oocyte development

Abstract Background During meiosis, the oocyte genome keeps dormant for a long time until zygotic genome activation. The dynamics and homeostasis of the maternal transcriptome are essential for maternal-to-zygotic transition. Zygotic arrest 1 (ZAR1) and its homolog, ZAR2, are RNA-binding proteins th...

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出版年:	Genome Biology
主要な著者:	Yu-Ke Wu, Ruibao Su, Zhi-Yan Jiang, Yun-Wen Wu, Yan Rong, Shu-Yan Ji, Jingwen Liu, Zhuoyue Niu, Zhiyi Li, Yuanchao Xue, Falong Lu, Heng-Yu Fan
フォーマット:	論文
言語:	英語
出版事項:	BMC 2025-05-01
主題:	Maternal-to-zygotic transition Meiosis RNA-binding proteins RNA polyadenylation Oocyte transcriptome
オンライン･アクセス:	https://doi.org/10.1186/s13059-025-03593-8