Cystatin from the helminth Ascaris lumbricoides upregulates mevalonate and cholesterol biosynthesis pathways and immunomodulatory genes in human monocyte-derived dendritic cells

BackgroundAscaris lumbricoides cystatin (Al-CPI) prevents the development of allergic airway inflammation and dextran-induced colitis in mice models. It has been suggested that helminth-derived cystatins inhibit cathepsins in dendritic cells (DC), but their immunomodulatory mechanisms are unclear. W...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Nathalie Acevedo, Ana Lozano, Josefina Zakzuk, Kevin Llinás-Caballero, David Brodin, Peter Nejsum, Andrew R. Williams, Luis Caraballo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-02-01
Subjects:	cystatin dendritic cells immunomodulation mevalonate pathway transcriptome
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1328401/full