Protection of HT22 neuronal cells against chemically-induced ferroptosis by catechol estrogens: protein disulfide isomerase as a mechanistic target

Abstract Ferroptosis is a form of regulated cell death, characterized by excessive iron-dependent lipid peroxidation. Biochemically, ferroptosis can be selectively induced by erastin through glutathione depletion or through inhibition of glutathione peroxidase 4 by RSL3, which leads to accumulation...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Xuanqi Huang, Ming-Jie Hou, Bao Ting Zhu
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-10-01
Subjects:	Protein disulfide isomerase Catechol estrogens Nitric oxide synthase Nitric oxide Reactive oxygen species Lipid reactive oxygen species
Online Access:	https://doi.org/10.1038/s41598-024-74742-5