A phosphodiesterase 4 (PDE4) inhibitor, amlexanox, reduces neuroinflammation and neuronal death after pilocarpine-induced seizure

Epilepsy, a complex neurological disorder, is characterized by recurrent seizures caused by aberrant electrical activity in the brain. Central to this study is the role of lysosomal dysfunction in epilepsy, which can lead to the accumulation of toxic substrates and impaired autophagy in neurons. Our...

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Bibliographic Details

Published in:	Neurotherapeutics
Main Authors:	Hyun Wook Yang, A Ra Kho, Song Hee Lee, Beom Seok Kang, Min Kyu Park, Chang Jun Lee, Se Wan Park, Seo Young Woo, Dong Yeon Kim, Hyun Ho Jung, Bo Young Choi, Won Il Yang, Hong Ki Song, Hui Chul Choi, Jin Kyu Park, Sang Won Suh
Format:	Article
Language:	English
Published:	Elsevier 2024-07-01
Subjects:	Epilepsy cAMP Phosphodiesterase4 Lysosome Autophagy Neuro-inflammation
Online Access:	http://www.sciencedirect.com/science/article/pii/S1878747924000436