Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes

Summary: A recurrent chromosomal translocation found in acute myeloid leukemia leads to an in-frame fusion of the transcription repressor ZMYND11 to MBTD1, a subunit of the NuA4/TIP60 histone acetyltransferase complex. To understand the abnormal molecular events that ZMYND11-MBTD1 expression can cre...

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發表在:	Cell Reports
Main Authors:	Maëva Devoucoux, Victoire Fort, Gabriel Khelifi, Joshua Xu, Nader Alerasool, Maxime Galloy, Nicholas Wong, Gaëlle Bourriquen, Amelie Fradet-Turcotte, Mikko Taipale, Kristin Hope, Samer M.I. Hussein, Jacques Côté
格式:	Article
語言:	英语
出版:	Elsevier 2022-06-01
主題:	ZMYND11 MBTD1 NuA4 TIP60 AML translocation
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S221112472200729X