Recipient TIM4 signaling regulates ischemia reperfusion-induced ER stress and metabolic responses in liver transplantation: from mouse-to-human

T-cell immunoglobulin and mucin (Tim)4 is expressed on APCs, including macrophages, as one of the main amplifiers in the mechanism of liver ischemia-reperfusion injury (IRI) following orthotopic liver transplantation (OLT). Though donor Tim4 selectively expressed on Kupffer cells serves as a checkpo...

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Bibliographic Details

Published in:	Frontiers in Transplantation
Main Authors:	Hirofumi Hirao, Shoichi Kageyama, Kojiro Nakamura, Kentaro Kadono, Hidenobu Kojima, Yao Siyuan, Douglas G. Farmer, Fady M. Kaldas, Kenneth J. Dery, Jerzy W. Kupiec-Weglinski
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-05-01
Subjects:	ischemia-reperfusion injury liver transplantation t-cell immunoglobulin and mucin domain containing 4 endoplasmic reticulum stress orthotopic liver tranplantation
Online Access:	https://www.frontiersin.org/articles/10.3389/frtra.2023.1176384/full