Targeting mutant p53: Evaluation of novel anti-p53R175H monoclonal antibodies as diagnostic tools

Abstract About 50% of all cancers carry a mutation in p53 that impairs its tumor suppressor function. The p53 missense mutation p53R175H (p53R172H in mice) is a hotspot mutation in various cancer types. Therefore, monoclonal antibodies selectively targeting clinically relevant mutations like p53R175...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Diana Spiegelberg, Le-Ann Hwang, Khian Hong Pua, Sashwini Chandra Kumar, Xin Yu Koh, Xiao Hui Koh, Ram Kumar Selvaraju, Kanaga Sabapathy, Marika Nestor, David Lane
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-01-01
Subjects:	Cancer diagnostics Mutant p53 Intracellular targets Molecular imaging
Online Access:	https://doi.org/10.1038/s41598-024-83871-w