Federated analysis of BRCA1 and BRCA2 variation in a Japanese cohort

Summary: More than 40% of the germline variants in ClinVar today are variants of uncertain significance (VUSs). These variants remain unclassified in part because the patient-level data needed for their interpretation is siloed. Federated analysis can overcome this problem by “bringing the code to t...

Full description

Bibliographic Details

Published in:	Cell Genomics
Main Authors:	James Casaletto, Michael Parsons, Charles Markello, Yusuke Iwasaki, Yukihide Momozawa, Amanda B. Spurdle, Melissa Cline
Format:	Article
Language:	English
Published:	Elsevier 2022-03-01
Subjects:	Variant of uncertain significance federated computing variant classification benign pathogenic data privacy
Online Access:	http://www.sciencedirect.com/science/article/pii/S2666979X22000295