An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders

Abstract Background Induced pluripotent stem cell-derived microglia (iMGL) represent an excellent tool in studying microglial function in health and disease. Yet, since differentiation and survival of iMGL are highly reliant on colony-stimulating factor 1 receptor (CSF1R) signaling, it is difficult...

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Bibliographic Details

Published in:	Molecular Neurodegeneration
Main Authors:	Marie-France Dorion, Diana Casas, Irina Shlaifer, Moein Yaqubi, Peter Fleming, Nathan Karpilovsky, Carol X.-Q. Chen, Michael Nicouleau, Valerio E. C. Piscopo, Emma J. MacDougall, Aeshah Alluli, Taylor M. Goldsmith, Alexandria Schneider, Samuel Dorion, Nathalia Aprahamian, Adam MacDonald, Rhalena A. Thomas, Roy W. R. Dudley, Jeffrey A. Hall, Edward A. Fon, Jack P. Antel, Jo Anne Stratton, Thomas M. Durcan, Roberta La Piana, Luke M. Healy
Format:	Article
Language:	English
Published:	BMC 2024-04-01
Subjects:	Microglia iPSC ALSP CSF1R Inflammation Phagocytosis
Online Access:	https://doi.org/10.1186/s13024-024-00723-x