Relationship between Plasma Concentrations of Afatinib and the Onset of Diarrhea in Patients with Non-Small Cell Lung Cancer

We evaluated the area under the plasma concentration–time curve (AUC) of afatinib required to avoid the onset of grade 2 or higher diarrhea. The C₀ and AUC_0–24 of afatinib were significant higher in patients with grade 2 diarrhea than in those with grade...

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Bibliographic Details

Published in:	Biology
Main Authors:	Hayato Yokota, Kazuhiro Sato, Sho Sakamoto, Yuji Okuda, Mariko Asano, Masahide Takeda, Katsutoshi Nakayama, Masatomo Miura
Format:	Article
Language:	English
Published:	MDPI AG 2021-10-01
Subjects:	afatinib diarrhea limited sampling strategy plasma concentration therapeutic drug monitoring
Online Access:	https://www.mdpi.com/2079-7737/10/10/1054