Metabolomic reprogramming of the tumor microenvironment by dual arginase inhibitor OATD-02 boosts anticancer immunity

Abstract Metabolic reprogramming within the tumor microenvironment (TME) plays a central role in cancer progression and immune evasion, with L-arginine metabolism emerging as a key regulatory axis. Arginase overexpression depletes intratumoral L-arginine, thus suppressing T-cell proliferation while...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Marcin Mikołaj Grzybowski, Yasemin Uçal, Angelika Muchowicz, Tomasz Rejczak, Agnieszka Kikulska, Katarzyna Maria Głuchowska, Małgorzata Szostakowska-Rodzoś, Agnieszka Zagożdżon, Tobias Bausbacher, Agnieszka Tkaczyk, Magdalena Kulma, Paulina Pomper, Michał Mlącki, Adam Konrad Jagielski, Roman Błaszczyk, Carsten Hopf, Zbigniew Zasłona
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-05-01
Subjects:	Dual arginase Inhibition OATD-02 MALDI imaging Metabolic reprogramming Arginine metabolism Polyamines
Online Access:	https://doi.org/10.1038/s41598-025-03446-1