PDGFRα+ Cells in Embryonic Stem Cell Cultures Represent the In Vitro Equivalent of the Pre-implantation Primitive Endoderm Precursors

In early mouse pre-implantation development, primitive endoderm (PrE) precursors are platelet-derived growth factor receptor alpha (PDGFRα) positive. Here, we demonstrated that cultured mouse embryonic stem cells (mESCs) express PDGFRα heterogeneously, fluctuating between a PDGFRα+ (PrE-primed) and...

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Bibliographic Details

Published in:	Stem Cell Reports
Main Authors:	Antonio Lo Nigro, Anchel de Jaime-Soguero, Rita Khoueiry, Dong Seong Cho, Giorgia Maria Ferlazzo, Ilaria Perini, Vanesa Abon Escalona, Xabier Lopez Aranguren, Susana M. Chuva de Sousa Lopes, Kian Peng Koh, Pier Giulio Conaldi, Wei-Shou Hu, An Zwijsen, Frederic Lluis, Catherine M. Verfaillie
Format:	Article
Language:	English
Published:	Elsevier 2017-02-01
Subjects:	embryonic stem cell heterogeneity pre-implantation PrE precursors in vitro model of early blastocyst development PDGFRα+ subpopulations
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213671116303009