Microglial deletion and inhibition alleviate behavior of post-traumatic stress disorder in mice

Abstract Background Alteration of immune status in the central nervous system (CNS) has been implicated in the development of post-traumatic stress disorder (PTSD). However, the nature of overall changes in brain immunocyte landscape in PTSD condition remains unclear. Methods We constructed a mouse...

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Bibliographic Details
Published in:Journal of Neuroinflammation
Main Authors: Shuoshuo Li, Yajin Liao, Yuan Dong, Xiaoheng Li, Jun Li, Yong Cheng, Jinbo Cheng, Zengqiang Yuan
Format: Article
Language:English
Published: BMC 2021-01-01
Subjects:
Mass cytometry
Microglia
Microglial depletion
Microglial activation
PTSD
Online Access:https://doi.org/10.1186/s12974-020-02069-9

Internet

https://doi.org/10.1186/s12974-020-02069-9

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