Brain Interleukin-1 Facilitates Learning of a Water Maze Spatial Memory Task in Young Mice

The proinflammatory cytokine interleukin-1 (IL-1) is produced by many types of cells, including immune cells in the periphery and glia and neurons in the brain. The type I IL-1 receptor (IL-1r1) is primarily responsible for transmitting the inflammatory effects of IL-1 and mediates several biologica...

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Bibliographic Details

Published in:	Frontiers in Behavioral Neuroscience
Main Authors:	Takako Takemiya, Kumiko Fumizawa, Kanato Yamagata, Yoichiro Iwakura, Marumi Kawakami
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-10-01
Subjects:	interleukin-1β (IL-1β) interleukin-1α (IL-1α) IL-1β knockout mice (IL-1βko) IL-1 receptor 1 (IL-1r1) IL-1r1 knockout mice (IL-1r1ko) water maze (WM)
Online Access:	http://journal.frontiersin.org/article/10.3389/fnbeh.2017.00202/full